Start-ups are one of the strongest engines for wealth creation, employment, and economic growth. India is aspiring to be a $5 trillion economy in the next five years. There is also a need to create 300 million jobs by 2040, which is roughly 10 million jobs a year. These aspirations and needs of India cannot just be fulfilled by the existing large enterprises alone. Start-ups can act as a vehicle to achieve the next level of economic growth and social development. India has begun its journey to becoming one of the fastest-growing start-up hubs in the world, and today, it is the third-largest in technology-driven product start-ups, after the U.S. and the U.K. The Global Entrepreneurship Monitor estimates some 20% of Indians (aged between 18 and 64 years) intend to start a business in the next three years, while more than 11% are nascent entrepreneurs. As entrepreneurs, innovators, academicians, and mentors to start-ups, in this third wave, Indians have an opportunity to rapidly prosper and put India on the path to becoming a developed nation. For this, we must explore new areas of entrepreneurial opportunities, develop new approaches, acquire relevant skills and mindset, and offer complete ecosystem support to successfully build deep-tech, IP-driven innovative platforms, products, and solutions from India, for the world.